The reason we're starting this now is because it might take a while for us to get our passports, and they may not be able to see us as soon as we'd like. Given the fact that my friend was told she just has two months to live, we want to get her started on something as soon as possible.
The things that appear to be the most helpful for killing pancreatic cancer cells, at last least so far as I've been able to research, are:
Oleanolic acid - found in olive leaf extract
Boswellic Acid - found in Holy Basil
Bowsellia - found in Frankincense
Ursolic Acid
Proleolytic Enzymes
Bromelain (only)
https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.2725
ABSTRACT
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits potential anti‐tumor activity against many tumor cell lines. This study aims to examine the anti‐tumor activity of OA on pancreatic cancer cells and its potential molecular mechanism. The results showed that the proliferation of Panc‐28 cells was inhibited by OA in a concentration‐dependent manner, with an IC50 (The half maximal inhibitory concentration) value of 46.35 µg ml−1, as determined by MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay. The cell cycle was arrested in S phase and G2/M phase by OA. The study also showed that OA could induce remarkable apoptosis, evidenced by an increased percentage of early/late apoptotic cells, DNA ladder and nuclear morphology change. Further study revealed that OA could induce Reactive Oxygen Species (ROS) generation, mitochondrial depolarization, release of cytochrome C, lysosomal membrane permeabilization and leakage of cathepin B. The expression of apoptosis‐correlated proteins was also affected in cells treated with OA, including activation of caspases‐3/9 and cleavage of PARP. Further study confirmed that ROS scavenger vitamin C could reverse the apoptosis induced by OA in Panc‐28 cells. Our results provide evidence that OA arrests the cell cycle and induces apoptosis, possibly via ROS‐mediated mitochondrial and a lysosomal pathway in Panc‐28 cells.
Oleanolic acid is found in olive leaf extract
Real European Olive Leaf Extract, 25% Oleuropein - Super-Strength, 500 mg, 90 capsules, plus Hydroxytyrosol Complex. Professional-Strength by Island Nutrition®
on May 13, 2017
In a week it is working for me.
Since the last summer I have some Intestinal problems. I didn’t have diahrrea, but now and then loose stool. Changes on the diet resulted with no effect.Tests for pathogene bacteria and parasytes resulted negative.
An Upper Endoscopy, a Colonoscopy, and a Capsule endoscopy resulted with negative results too.
So the health care system let me go for good, and I was on my OWN.
Started oregano oil extract and coconut oil, continued for 4 months with no effects.
Last summer I started Olive Leaf Extract Super Strength Standardized for 20% or 150 mg of oleuropein, but two days after I did a big mistake. While taking Olive Leaf Extract, I took Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine. I never was allergic for anything for all my life, but this time it was different. The next day the injection spot turned read and was eatching. Immediatelly I stopped taking Olive Leaf Extract. The other day the red area enlarget as big as the palm of the hand. The therd day I went to the doctor. He was alarmed and adviced me to go to the hospital. I declined and he used a black marker, starting from the shoulder to the elbow, while I was leaving he told me: if it is going to grow bigger than marked area then go to E.R.
In fact it took about 10 days to normlize. I was scared to use Olive Leaf Extract because of this reaction.
After health care system let me to go for good, and the loose stool was persistent, I decided to give another try.
I started taking Spanish Olive Leaf Extract 25% Oleuropein. The result was imminent. I started Low and slow with 1 Capsule per day. After 3 days I encreased to 2 capsules per day. In a week my intestin is normalised. I plan to encrease to 3 capsules per day for some time, and after go to a maintenance dose 2 capsules per day.
Based on my opinion the Olive Leaf Extract is very potent. It can create strong alergic reactions with vacines, and the human body tolerates it well. If used for treatment of different medical condition Start Low and slow but to have effect you must reach a lethal dosage for the pathogen and stay in this level for a while before going down to a maintenance dose.
The ability of cancer and pathogens to evolve, and adapt is a principal challenge to therapy in general and to the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of multiple, genetically heterogeneous subpopulations within the cancer and pathogens cell population. Increasing evidence has supported the idea that these subpopulations are selected in a Darwinian fashion, by which the genetic landscape of the tumor or infection is continuously reshaped. This may happen while using semi lethal doses for the pathogen.
Since the last summer I have some Intestinal problems. I didn’t have diahrrea, but now and then loose stool. Changes on the diet resulted with no effect.Tests for pathogene bacteria and parasytes resulted negative.
An Upper Endoscopy, a Colonoscopy, and a Capsule endoscopy resulted with negative results too.
So the health care system let me go for good, and I was on my OWN.
Started oregano oil extract and coconut oil, continued for 4 months with no effects.
Last summer I started Olive Leaf Extract Super Strength Standardized for 20% or 150 mg of oleuropein, but two days after I did a big mistake. While taking Olive Leaf Extract, I took Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine. I never was allergic for anything for all my life, but this time it was different. The next day the injection spot turned read and was eatching. Immediatelly I stopped taking Olive Leaf Extract. The other day the red area enlarget as big as the palm of the hand. The therd day I went to the doctor. He was alarmed and adviced me to go to the hospital. I declined and he used a black marker, starting from the shoulder to the elbow, while I was leaving he told me: if it is going to grow bigger than marked area then go to E.R.
In fact it took about 10 days to normlize. I was scared to use Olive Leaf Extract because of this reaction.
After health care system let me to go for good, and the loose stool was persistent, I decided to give another try.
I started taking Spanish Olive Leaf Extract 25% Oleuropein. The result was imminent. I started Low and slow with 1 Capsule per day. After 3 days I encreased to 2 capsules per day. In a week my intestin is normalised. I plan to encrease to 3 capsules per day for some time, and after go to a maintenance dose 2 capsules per day.
Based on my opinion the Olive Leaf Extract is very potent. It can create strong alergic reactions with vacines, and the human body tolerates it well. If used for treatment of different medical condition Start Low and slow but to have effect you must reach a lethal dosage for the pathogen and stay in this level for a while before going down to a maintenance dose.
The ability of cancer and pathogens to evolve, and adapt is a principal challenge to therapy in general and to the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of multiple, genetically heterogeneous subpopulations within the cancer and pathogens cell population. Increasing evidence has supported the idea that these subpopulations are selected in a Darwinian fashion, by which the genetic landscape of the tumor or infection is continuously reshaped. This may happen while using semi lethal doses for the pathogen.
Best Olive Leaf Extract (NON-GMO) 750 mg - 20% Oleuropein - Vegetarian - Super Strength - Immune Support, Cardiovascular Health & Antioxidant Supplement - No Oil - 120 Capsules
on June 4, 2018
I have purchased this product (Best Olive Leaf Extract 750mg) several times and feel it is a quality product and wouldn't be without it. It helps to boost the immune system. Due to my husband battling stage 4 cancer we have to be really careful with our exposure to bugs (germs), this has helped us to both keep from getting colds, flu, etc as part of our immunity boosting program that we have created and so far has worked.
Boswellic Acid is found in Holy Basil
Holy Basil Leaf Extract Decreases Tumorigenicity and Metastasis of Aggressive Human Pancreatic Cancer Cells in vitro and in vivo: Potential Role in Therapy
3.3 EEOL induce apoptosis of pancreatic cancer cells
The effect of EOOS and EEOL on PC cell cycle progression was evaluated (Figure 3A). Overall, the effect of basil extracts on cell cycle progression was not conclusive. In AsPC-1 cells, EOOS decreased the percentage of cells in the G2/M-phase, whereas there was an increase in the S phase and no significant effect was noted on the G1 phase. On the other hand, in MiaPaCa cells, both EOOS and EEOL extracts appeared to promote the progression through the cell cycle as evidenced by a decrease in the percentage of EOOS and EEOL treated cells in the G1 phase and an increase in the percentage in the S and G2/M phases. Nevertheless, the percentage of apoptotic and necrotic cells after basil extract treatment was analyzed after Annexin V-propidium iodide staining and the results revealed the percentage of apoptotic cells was significantly higher upon treatment with EEOL, revealing the cytotoxic mechanism of the extract on PC cells.
3.4 EEOL/EOOS downregulates the expression of proteins that promote pancreatic cancer invasion and metastasis
As we had observed a significant inhibition of motility and invasion of PC cells by EEOL and EOOS, we also sought to investigate whether there was a change in the molecular pathways mediating these functions. For this, AsPC-1 cells were treated with either EEOL or EOOS for 48 hours followed by western blotting and Real time RT-PCR to examine the change in the expression of key proteins and genes. Both EEOL and EOOS significantly decreased the activation of the key mediators of PC cell survival, proliferation, metastasis, invasion and chemoresistance: the extracellular signaling regulated kinase (ERK-1/2) and focal adhesion kinase (FAK) (Figure 4A). Activation of NF-kB, specifically the p65 subunit, is known to be a key activator of pathways that promote proliferation, invasion and metastasis [26]. Both EEOL and EOOS downregulated the protein expression of the p65 subunit of NF-κB in PC cells suggesting that inhibition of NF-kB is one of the possible mechanisms by which basil oil or leaf extract inhibits the aggressive behavior of PC cells (Figure 4A).
Correction
8 Aug 2012: Park B, Prasad S, Yadav V, Sung B, Aggarwal BB (2012) Correction: Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets. PLOS ONE 7(8): 10.1371/annotation/d4645c95-739f-4175-b753-b6fe0ba6063c.https://doi.org/10.1371/annotation/d4645c95-739f-4175-b753-b6fe0ba6063c View correction
Abstract
Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata.Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa. We found that AKBA inhibited the proliferation of four different PaCa cell lines (AsPC-1, PANC-28, and MIA PaCa-2 with K-Ras and p53 mutations, and BxPC-3 with wild-type K-Ras and p53 mutation). These effects correlated with an inhibition of constitutively active NF-κB and suppression of NF-κB regulating gene expression. AKBA also induced apoptosis, and sensitized the cells to apoptotic effects of gemcitabine. In the orthotopic nude mouse model of PaCa, p.o. administration of AKBA alone (100 mg/kg) significantly inhibited the tumor growth; this activity was enhanced by gemcitabine. In addition, AKBA inhibited the metastasis of the PaCa to spleen, liver, and lungs. This correlated with decreases in Ki-67, a biomarker of proliferation, and CD31, a biomarker of microvessel density, in the tumor tissue. AKBA produced significant decreases in the expression of NF-κB regulating genes in the tissues. Immunohistochemical analysis also showed AKBA downregulated the expression of COX-2, MMP-9, CXCR4, and VEGF in the tissues. Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets.
NOW Holy Basil Extract 500 mg,90 Veg Capsules
on September 21, 2017
This is a wonder herb that has many medicinal qualities. The main purpose for buying it is it is beneficial for cancer treatment. It prevents the cells from multiplying and it helps with your skin when you are undergoing radiation therapy. The oncologist asked me what I was doing and to keep it up because other than some minor discoloration, my skin looks good. I do use a few drops of Tulsi essential oil with lotion in the evenings in addition to taking 2 capsules a day of the Holy Basil (Tulsi)
ORGANIC INDIA Tulsi - Holy Basil Supplement - Made with Certified Organic Herbs (Vegetarian Capsules, 90 Count)
New Chapter Holy Basil Force with Supercritical Holy Basil for Immune Support + Mood Support + Non-GMO Ingredients - 120 ct Vegetarian Capsules
on July 5, 2014
This stuff rocks! It 100% works! When I first took it, I was monitoring "what it would do to me." For me, it takes about 45min to an hour before it kicks in and...it just makes me feel good. Noticebly and physically good. Dare I say slightly high (not in the drug sense)....just really good, positive and focused. It helps me work...and it especially helps because I do a lot of large-scale public speaking. I also noticed that when I combined a dose of Holy Basil and Zyflamend Whole Body--many issues with my knees and back seem to disappear. After deeper review of Holy Basil (also known as Tulsi)--I found out that this has much more benefits than I thought. It promotes circulation in the body (big one right there) and is an epic contender for improving heart function and repairing heart damage. Its an anti-inflammatory without the side effects. Check this out from WebMD:
"Holy basil is used for the common cold, influenza ("the flu"), H1N1 (swine) flu, diabetes, asthma, bronchitis, earache, headache, stomach upset, heart disease, fever, viral hepatitis, malaria, stress, and tuberculosis. It is also used for mercury poisoning, to promote longevity, as a mosquito repellent, and to counteract snake and scorpion bites.
Holy basil is applied to the skin for ringworm.
HOW DOES IT WORK?
Chemicals in holy basil are thought to decrease pain and swelling (inflammation). Other chemicals might lower blood sugar in people with diabetes.
There is interest in using holy basil seed oil for cancer. Beginning research suggests that the oil can slow progression and improve survival rate in animals with certain types of cancer. Researchers think this benefit may be explained by the oil’s ability to act as an antioxidant."
Though no serious side effects or dangers have been reported--some health officials say you should be cautious if you are taking any 'blood thinning' medications for heart. Once again, no side-effects or dangers have been reported--just a recommendation from a few health officials.
All in all, I feel this has certainly improved the quality of my life.
"Holy basil is used for the common cold, influenza ("the flu"), H1N1 (swine) flu, diabetes, asthma, bronchitis, earache, headache, stomach upset, heart disease, fever, viral hepatitis, malaria, stress, and tuberculosis. It is also used for mercury poisoning, to promote longevity, as a mosquito repellent, and to counteract snake and scorpion bites.
Holy basil is applied to the skin for ringworm.
HOW DOES IT WORK?
Chemicals in holy basil are thought to decrease pain and swelling (inflammation). Other chemicals might lower blood sugar in people with diabetes.
There is interest in using holy basil seed oil for cancer. Beginning research suggests that the oil can slow progression and improve survival rate in animals with certain types of cancer. Researchers think this benefit may be explained by the oil’s ability to act as an antioxidant."
Though no serious side effects or dangers have been reported--some health officials say you should be cautious if you are taking any 'blood thinning' medications for heart. Once again, no side-effects or dangers have been reported--just a recommendation from a few health officials.
All in all, I feel this has certainly improved the quality of my life.
Gaia Herbs Holy Basil Leaf, Vegan Liquid Capsules, 120 Count - For Stress Relief and Healthy Inflammatory Response, Nourishes the Mind and Elevates the Spirit, Tulsi Extract (8.5 mg Eugenols)
Bowsellia is found in Frankincense
Superior Labs Boswellia Extract - Pure NonGMO Boswellic 65% Acids w/Bioperine Superior Absorption Zero Synthetic Additives - Powerful Formula Joint, Knees, Hips, Migraine, Immune, - 500mg Svg, 240 Veg
https://www.ncbi.nlm.nih.gov/pubmed/23237355
Labrada Nutrition Ursolic Acid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914350/
Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment
UA inhibits distant organ metastasis from orthotopically implanted pancreatic cancer in nude mice
At autopsy, the mice in each treatment group were examined for the presence of metastases. The results showed that pancreatic cancer metastasis developed more frequently in the spleen and liver of vehicle-treated mice than in mice treated with UA or gemcitabine alone. UA and gemcitabine respectively decreased to 33.3% and 22.2% metastasis of pancreatic cancer cells in spleen while in liver it decreased to 30% and 35%. Maximum inhibition of metastasis, however, was observed in the group treated with the combination of UA and gemcitabine 66.6% in spleen and 65% in liver (Figure (Figure4A4A).
Please note: I looked into gemcitabine which is a chemotherapy drug, and it appears that THIS STUDY, which found gemcitabine to work better than proleolytic enzymes, was highly biased. You can read a bit about that study, HERE. So, I am still going to go ahead and order the Urolic acid for my friend, along with proleolytic enzymes.
UA inhibits the expression of biomarkers linked to tumor survival, proliferation, and metastasis in orthotopically implanted pancreatic tumors
Next we examined whether UA modulates the expression of proteins involved in cell survival, invasion, and metastasis in orthotopically implanted pancreatic tumors. Western blotting revealed significant reductions in the expression of markers for cell survival (survivin and Bcl-2), proliferation (cyclin D1), inflammation (COX-2), and metastasis (ICAM-1 and MMP-9) in tumors from the groups treated with UA or gemcitabine alone compared with those from the control group. However, gemcitabine in combination with UA was more effective in suppressing the expression of these proteins than either UA alone or gemcitabine alone (Figure (Figure5C5C).
Immunohistochemical analysis of pancreatic tumor tissues also revealed that UA, alone or in combination with gemcitabine, significantly decreased the expression of cyclin D1, COX-2, VEGF, and MMP-9 molecules compared with the control treatment (Figure (Figure6A6A).
Proleolytic Enzymes
https://thetruthaboutcancer.com/systemic-proteolytic-enzymes/
How Systemic Proteolytic Enzymes Fight Cancer
Enzymes play a vital role in human health and well-being. They are imperative for optimal digestion, nutrient absorption, immune response, cognitive thinking, and systemic cellular detoxification, among many other life-essential processes. Since the early 1900s enzyme therapy has been used as a natural protocol to heal cancer and has showed tremendous promise.
Enzymes are protein structures which take on different shapes and are designated for different purposes, such as one might compare a lock and key model. Enzymes are some of the most important structures in your body. They help heal and support good immune response to help prevent disease and cancer.
Systemic enzymes are formulated to reach the bloodstream fully intact and not become dissolved in stomach acid. To ensure optimal absorption, systemic proteolytic enzymes should be consumed on an empty stomach. This allows for their passage into the bloodstream where they can then be circulated throughout the entire body. Specific protease enzymes which break down protein have been found to have a powerful impact on fighting inflammatory and fibrinolytic activity (blood clot formation).Dosing Recommendations for Enzyme Therapy
Cancer Prevention: 5 to 20 grams daily. Preferably 10 capsules in the morning and 10 capsules before bed.
Cancer Patients: 20 to 80 grams proteolytic enzymes daily. Dosage split into 30 capsules in the morning, 20 capsules 3 hours later (preferably 2 hours before and after eating), and 30 capsules before bed.
Metastatic Cancer Patients: 45 to 160 grams daily split into 40 capsules in the morning, 40 capsules later, and 80 capsules before bed.
Pro-OneZyme Best Proteolytic Systemic Enzymes with Nattokinase and Seaprose - 90 capsules
These ingredients include Bromelain, Nattokinase, Papain, Peptidase, Protease, Seaprose, Catalase, Rutin and Calcium Citrate.
Bromelain (only)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998156/
Potential role of bromelain in clinical and therapeutic applications
Effect on angiogenesis and metastasis
The metastatic spread of tumor cells from the original site is the cause of the high mortality rates associated with cancer. There are at least four interrelated biological events required for tumor metastasis: Angiogenesis, cell adhesion, cell invasion and cell proliferation (52). The interesting aspect of the anticancer activity of bromelain is its inhibitory effect on cancer metastasis. Bromelain potentially interferes with tumor metastasis progression at a variety of pivotal points (53). Bromelain inhibits cell surface adhesion proteins that are essential in cell adhesion, migration and inflammation (54). This inhibition is predominantly due to suppression of NF-κB activation. Furthermore, bromelain inhibits the invasiveness of human cancer cells by suppressing matrix metalloproteinase (MMP)-9 expression (55,56) through inhibiting activator protein 1 (AP-1) and NF-κB signaling pathways (42,57). A previous study demonstrated that bromelain initially suppresses the phosphorylation of NF-κB activation and then decreases the phosphorylation of c-Jun N-terminal kinases and subsequently AP-1 activation (58). In malignancies, there is a mutual association between platelets and tumor cells. Tumor cells initiate platelet activation, as well as the platelet-based production of multiple factors facilitating angiogenesis. Additionally, tumor cells, to varying degrees, possess the capacity to surround themselves with platelets, forming tumor-platelet aggregates that protect tumor cells from immune recognition (59). Oral administration of bromelain, as assessed by in vitro assays resulted in a reduction of platelet aggregation and activation (60). A previous study demonstrated that in vitro bromelain treatment of platelets from healthy volunteers significantly reduced platelet count (61). The ability of bromelain to inhibit platelet activation is associated with its proteolytic activity (17). Thus, the anti-platelet activity of bromelain interferes with platelet-mediated cancer growth and progression, and prevents the generation of tumor-platelet aggregates by un-coating cancer cells and exposing them to the immune system (62).
Superior Labs – Best Bromelain Non GMO Natural Supplement – Non-Synthetic – 2,400 gdu/gram – Supports Healthy Digestion & Inflammatory Responses, Bruises, Immune – Extra Strength – 500 mg, 120 VCaps
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